Chemical Structures and Excipient Profile of Drugs

Chemical Structures and Excipient Profile of Drugs DRUG AND EXCIPIENT PROFILE CAFFEINE Chemical structure : Mol. Weight : Average: 194.1906 Melting point : 238  °C State : solid Water solubility : 2.16E+004 mg/L (at 25  °C) Half Life : 3 – 7 hours in geriatrics , 65 – 130 hours in pediatrics Protein Binding : Low protein binding (25 – 36%) Absorption : absorbed after oral and parenteral administration. The peak plasma level of caffeine ranges from 6 to 10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours. Pharmacology : Caffeine is a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline. It is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other types of headache. Over the counter, caffeine is used to treat drowsiness or mild water-weight gain. Mechanism of Action : Caffeine stimulates med ullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3†²,5†²-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. Xanthines such as caffeine act as antagonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of nor epinephrine or angiotensin, antagonist of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockage of the adenosine A1 receptor in the heart leads to the accelerated, pronounced â€Å"pounding† of the heart upon caffeine intake. Indication : For management of fatigue, orthostatic hypotension, and for the short term treatmen t of apnea of prematurity in neonates. Toxicity : LD 50 = 127 mg/kg (oral dose in mice) ERGOTAMINE Chemical structure : Mol. Weight : Average: 581.6615 Melting point : 213.5  °C State : solid state Water solubility : Slightly soluble Half Life : 2 hours Absorption : The bioavailability of sublingual ergotamine has not been determined. Pharmacology : Ergotamine is a vasoconstrictor and alpha adrenoreceptor antagonist. The pharmacology of ergotamine is extremely complex; some of its actions are unrelated to each other, and even mutually antagonistic. The drug has partial agonist and antagonist activity against tryptaminergic, dopaminergic and alpha adrenergic receptors depending upon the site, and is highly active uterine stimulant. It causes constriction of peripheral and cranial blood vessels and producing depression of central vasomotor centers. The pain of a migraine attack is due to increased amplitude of pulsations in the cranial arteries, especially the m eningeal branches of the external carotid artery. Ergotamine reduces extra cranial blood flow, causes a decline in the amplitude of pulsation in the cranial arteries, and decreases hyper perfusion of the territory of the basilar artery. It does not reduce cerebral hemispheric blood flow. Mechanism of Action : Ergotamine acts on migraine by one of the two proposed mechanisms: 1) activation of 5-HT 1D receptors located on intracranial blood vessels, including those on arteriole-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine, and 2) Activation of 5-HT 1D receptors on sensory nerve endings of the trigeminal system which results in inhibition of pro-inflammatory neuropeptide release. Indication : For use as therapy to abort or prevent vascular type of headache, e.g., migraine, migraine variants, or so called â€Å"histaminic cephalalgia†. Toxicity : Signs of overexposure including irritation, nausea, vomiting, headache, diarrh ea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion. CYCLIZINE

Integrating Civics Educations into Liberal Studie Essay

Integrating Civics Educations into Liberal Studie - Essay Example In this subject are elements of humanities, science and liberal arts, which serves to help learners have a broad outlook after completing their senior secondary level studies. Some of the areas of study in this subject include self and personal development, personal identity, and preparing for adulthood, role of an individual and society, conflict resolution and interpersonal relationship, economic restructuring, the rule of law and participation in society and politics, and finally the general quality of life (Chan, and Sin, 2005). Likewise, the curriculum development council has proposed that civic education be also introduced in both elementary and secondary schools. In the past, civic education has never been made a complete and independent subject in Hong Kong. However, recently, civic education has been strengthened, and is embedded in other subjects such as history and Chinese among others. The major aim for this subject is to strengthen learners positive attitudes and values, develop good civic and personal qualities and also create an individual vision in committing and contributing to one’s country, family and the world. The general concepts, points and evaluation mode are very powerful and strict. It has been argued that integrating this subject to liberal studies will facilitate the achievement of the goal of a making a balanced and well-rounded person, rather than making it an independent subject (China Daily, Jun 1 2011 8:42). The purpose of introducing liberal studies in China’s New Secondary Curriculum is to broaden the student’s knowledge base as well as enhance their social awareness through studying a wide range of issues. The module in the curriculum focuses on the themes, which are of significance to the society, students and the world in general. These are designed in such a way that students are enabled to make connections across various fields of knowledge

Law Assignment Essay Example | Topics and Well Written Essays - 2250 words

Law Assignment - Essay Example It is in this context that the parliament makes laws in order to govern the citizens of a country suitably, which are recognized as statue laws. The parliament comprises elected representatives entrusted with the responsibility of making laws in order to ensure that the states and the societies are governed effectively in such cases (Brassil & Brassil, 2000). Nevertheless, such courtroom practices have also been alleged of raising various ethical issues concerning the application of the enacted regulations and the various facets of the particular event being scrutinized. These arguments and skepticisms demand for a more organized and cautious judgment in cases, so that ethical conflicts can be avoided when ruling a particular case. The statement, â€Å"Judges should be cautious (in terms of making law or following precedent) not because the principles adopted by the Parliament are more satisfactory or more enlightened, but because it is unacceptable constitutionally that there shoul d be two independent sources of law-making at work at the same time† postulates a similar notion, which will be critically discussed henceforth, with reference to relevant case laws. Factually, common laws are formed with the sole intention to direct or steer the decisions made by judges are to be followed in future identical cases presented before the court. Case laws are identified as the main sources of common law, whilst the prior formulated laws are still considered important in the present day context. There are two important sources that assist in the overall development of common law, which include the ‘doctrine of precedent’ and the parliament. The doctrine of precedent is an important source of law in accordance with which, judges can make their decisions in present cases based on the decisions delivered in previous instances. The doctrine of precedent usually implies the deontological belief that lower courts are required to make their decisions in pres ented cases on the basis of decisions that are delivered in landmark cases presenting similar legal conflicts and issues. Contextually, the judges are assigned with the tasks of having a better understanding of the facts as well as information in relation to certain cases. Moreover, the judges are also required ensure that the decisions made can be applicable to later cases ascertaining that on the identification of similar facts as well as information, the judges are able to make their decisions effective, based on the decisions made in previous cases. In this context, the doctrine of precedent can be regarded as an important source of common law assisting judges in taking appropriate decisions ensuring the omission of mentionable ethical conflicts (Pearson Education Ltd, 2014). For an example, the decisions made in the case Shaw v DPP [1962] AC 220 have been used by the judges in the case of Knuller v DPP [1973] AC 435 following the Parliamentary norms (e-lawresources, n.d.). On t he other hand, there were cases like Jackson and others v. Her Majesty's Attorney General [2005] UKHL 56 (House of Lords, 2006) and British Railways Board v Pickin [1974] UKHL 1 (United Kingdom House of Lords Decisions, 1974) where judges ruled with the application of the purposive methods, delivering dissenting judgments to the propounded norms by the Parliament. This further raises a noteworthy question and a degree of perplexity regarding the applicable laws and the independency of judges in ruling any particular case. Worth mentioning, the parliament is entrusted with the responsibility of making laws on the basis of which, people are to be